Date of Conference
August 1-5th, 2010
June 25, 2010
Last date to get special rates for the Grand Hyatt Hotel
Conference Rates Available From: 07/25/10 - 08/12/10
Conference Rates:
Single- $209
Double- $209
Triple - $209
Quad - $209
Email:Berhane Ghebrehiwet
Program Overview
Monday, August 2, 2010
8:00 am - 6:00pm
All oral presentations are 10 min, with 5 min for questions. Presenters must load their power-point presentations on the session file at least one day prior to presentation. Speaker services will be available on site.
| 8:00 - 9:00 AM | Breakfast | |
| 9:00 - 9:30 AM | Openening Ceremony | Berhane Ghebrehiwet/ |
| Session: Complement Structure & Function | ||
| 9:30 AM | MUTATIONAL ANALYSIS OF LIGAND-BINDING ACTIVITIES OF RECOMBINANT gC1q HETEROTRIMER Mihaela Gadjeva1, Alexandra Zlatarova2, Marieta Ruseva3, Uday Kishore4 and Mihaela Kojouharova5 |
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| 9:45 AM | Crystal structure of C3bB in complex with factor D Federico Forneris (a), Jin Wu (a), Rachel S. Wallace (a), Apostolia Tzekou (b), Daniel Ricklin (b), John D. Lambris (b,*) and Piet Gros (a,*). |
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| 10:00 AM | Characterization of the interactions between C3b and complement regulators |
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| 10:15 AM | Biophysical Investigations of Complement Receptor 2 (CR2, CD21) Ligand Interactions Reveal Specific Amino Acid Contacts Unique to Each Receptor-Ligand Pair |
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| 10:30 AM | A new possible mechanism for target discrimination of the alternative pathway revealed by structural and functional studies of factor H domains 19-20 and C3d |
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| 10:45 AM | Analysis of binding sites on complement Factor I that are required for its activity Jose I. Sanchez Gallego1, Izabela M. Nita1, Sara C. Nilsson1, Tom W.L. Groeneveld1, Bruno O. Villoutreix2, and Anna M. Blom1. |
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| 11:00 -11:15AM | BREAK | |
| Session: Activation and Regulation - I | ||
| 11:30 AM | MBL/MASP-1 complexes efficiently cleave a zymogen of complement factor D Minoru Takahashi1, Daisuke Iwaki1, Yuichi Endo1, Kazue Takahashi2, Gregory L. Stahl3, Teizo Fujita1 |
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| 11:45 AM | MBL/Ficolin associated protein-1 (MAP-1) may function as a local lectin pathway specific complement inibitor Mikkel-Ole Skjødt, Tina Hummelshøj, Yaseelan Palarasah, Christian Honore, Claus Koch, Karsten Skjødt and Peter Garred |
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| 12:00 PM | Autoactivation of MASP-2: role of exosite interactions Veronika Harmat a,b, Andrea Kocsis c, Anna Kiss-Szemán b, Gábor Pál d, Péter Závodszky c, Péter Gál c |
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| 12:15 PM | Multiple domains of MASP-2, an initiating complement protease, are required for interaction with C4 Renee C Duncan1, Lakshmi C Wijeyewickrema1, Frida Bergström2, Anna M Blom2 and Robert N Pike1. |
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| 12:30 - 1:15 PM | LUNCH | |
| 1:30 - 2:15 PM | PLENARY SESSION: The Plasma Bradykinin Forming Pathways and its Interrelationships with Complement |
Allen P. Kaplan, M.D. |
| Session: Activation and Regulation - II | ||
| 2:15 PM | Properdin is required for autologous tissue injury but not systemic complement consumption associated with uncontrolled alternative pathway activation Allison M. Lesher1, Yuko Kimura1, Damodar Gullipalli1, Lin Zhou1, Andrew P Herbert2, Paul Barlow2, Christina Skerka3, Peter Zipfel3, Takashi Miwa1 and Wen-Chao Song1 |
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| 2:30 PM | Properdin homeostasis requires the turnover of alternative complement pathway Xiaobo Wu, Thomas Q. Xu, and John P. Atkinson |
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| 2:45 PM | Building up a picture of C7 on the basis of high-resolution structure of its component modules Carla Clark1 , Marie Phelan1, Sarah Ford2, Ronald Ogata2, Janice Bramham1, and Paul N. Barlow1 |
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| 3:00 PM | Structural insights into the initiation of the Terminal Pathway Michael A. Hadders, Michael K. Pangburn, Dmitri I. Svergun, Piet Gros |
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| 3:15 PM | IL-4 induces up-regulation of the junction protein claudin-5 in vascular endothelial cells, which is required for protection from killing by the membrane attack complex Karen R. Wasiluk, Daniel Goldish, Barbara A. Benson, Gregory Vercellotti and Agustin P. Dalmasso |
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| 3:30PM | BREAK | |
| Session: Innative and Adaptive Immunity - I | ||
| 3:45 PM | The Classical and Alternative Complement Pathways Play Different Roles in the Immune Response Michael M. Frank, Garren Hester, Haixiang Jiang, HuaMei Zhang, David DiLillo, Garnet Kelsoe, Amanda Hauck |
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| 4:00 PM | Direct interaction between CD91 and C1q K. Duus1, E. W. Hansen2, P. Tacnet3, P. Frachet3, G. J. Arlaud3, N.M. Thielens3, G. Houen1 |
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| 4:15 PM | Lymph node macrophages bind influenza virus in an MBL-dependent manner but they are not required for humoral immunity to influenza. Santiago F. Gonzalez1, Søren E. Degn1,2, Michael P. Kuligowski1, Lisa A. Pitcher1, Mary Cloninger3, Michael C. Carroll1 |
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| 4:30 PM | Reduced B cell anergy in mice deficient in CD21 Michael C. Carroll, Minghe Ma, Amma Agemang |
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| 4:45 PM | Differential expression and function of complement receptor type 1 (CD35) and 2 (CD21) on various human B lymphocyte subsets Erdei,A. Kremlitzka M., Isaák A., Prechl J.,Bajtay Z. |
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| 5:00 - 6:00 PM | POSTER SESSION - 1 | |