Date of Conference
August 1-5th, 2010
June 25, 2010
Last date to get special rates for the Grand Hyatt Hotel
Conference Rates Available From: 07/25/10 - 08/12/10
Conference Rates:
Single- $209
Double- $209
Triple - $209
Quad - $209
Email:Berhane Ghebrehiwet
Program Overview
Wednesday, August 4, 2010
7:00 am - 6:00pm
All oral presentations are 10 min, with 5 min for questions. Presenters must load their power-point presentations on the session file at least one day prior to presentation. Speaker services will be available on site.
| 7:00 - 8:00 AM | Breakfast | |
| 8:00 - 9:00 AM | POSTER SESSION - 4 | |
| Session: Animal Models of Disease - II | ||
| 9:00 AM | Accelerated Development of Lupus Nephritis in MRL-lpr Mice Lacking Complement Factor H Lihua Bao, Mark Haas, Richard J. Quigg |
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| 9:15 AM | C5aR Negatively Regulates In Vivo and In Vitro Production of IL-17A Peter A. Ward, Markus Bosmann, J. Vidya Sarma, Ketong Zhu, Firas S. Zetoune |
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| 9:30 AM | Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of E. coli sepsis Florea Lupu (1,6), Robert Silasi-Mansat (1), Hua Zhu (1), Narcis I. Popescu (1,6), Glenn Peer (2), Georgia Sfyroera (5), Paola Magotti (5), Lacramioara Ivanciu (1), Cristina Lupu (1), Tom E. Mollnes (3,4), Fletcher B. Taylor (1,6), Gary Kinasewitz (2) and John D. Lambris (5) |
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| 9:45 AM | Mice lacking the C3a receptor (C3aR) are susceptible to Listeria monocytogenes systemic infection despite having an elevated CD4+ Th1 cytokine response Stacey L. Mueller-Ortiz, John E. Morales, and Rick A. Wetsel. |
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| 10:00 AM | Inhibition of Complement Activation Prevents Features of Preeclampsia in a Mouse Model Shari E Gelber, MD, PhD(1), Patricia B Redecha(2), Stephen Tomlinson, PhD(3), Robin L Davisson, PhD(1) and Jane E Salmon, MD(2) |
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| 10:15 AM | The Role of Complement-Mediated Inflammation in Miscarriage and Preterm Birth Costantini KJ(1), Coulthard LG(1,) Woodruff TM(1), Taylor SM(1), Callaway LK(2) |
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| 10:30 -10:45 AM | BREAK | |
| Session: Complement and Disease - I | ||
| 11:00 AM | Mutations in Complement Regulatory Proteins Predispose to Preeclampsia Jane E. Salmon1, Michael Triebwasser2, M. Kathryn Liszewski2, David Kavanagh3, Cara Heuser4, Lubka Roumenina5, Ware Branch4, Tim Goodship3, Veronique Fremeaux-Bacchi5, John P. Atkinson2 |
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| 11:15 AM | Impaired ability of complement activation via the alternative pathway C3 convertase caused by a single-point mutation in the beta chain of C3 Georgia Sfyroera (1), Daniel Ricklin (1), Hui Chen (1), Kristina Nilsson-Ekdahl (2), Bo Nilsson (2), Emilia L. Wu (3), Yiannis N. Kaznessis (3), John D. Lambris (1) |
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| 11:30 AM | The common C3F/S polymorphism, R102G, alters factor H regulation of the alternative pathway convertase and combines with other complement variants to influence complement activity in plasma Meike Heurich1, Ruben Martínez-Barricarte2, Nigel J Francis1, Dawn L Roberts1, Santiago Rodríguez de Córdoba2, B Paul Morgan1, Claire L Harris1 |
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| 11:45 AM | Human C3 mutation associated with Dense Deposit Disease unravels distinct structural requirements for factor H, MCP and DAF regulation Rubén Martínez-Barricarte1, Meike Heurich2, Francisco Valdes-Cañero3, Eduardo Vazquez-Martul3, Eva Torreira1, Tamara Montes1, Agustín Tortajada1, Sheila Pinto1, Margarita Lopez-Trascasa4, B. Paul Morgan2, Oscar Llorca1, Claire L Harris2 and Santiago Rodríguez de Córdoba1 |
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| 12:00 PM | Double deficiency of C5aR/C3aR significantly prevents mice from renal ischemia/reperfusion injury Qi Peng, Guolan Xing, Ke Li, Naiyin Wang, Steven H. Sacks, Wuding Zhou |
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| 12:15 PM | C5aR Protects Against Folate-Deficiency Induced Neural Tube Defects in Mice Costantini KJ (1,2) , Coulthard LGJ (1) , Lor M (1), Woodruff TM (1), Callaway LK (2), Finnell RH (3) and Taylor SM (1) |
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| 12:30 - 1:15 PM | LUNCH | |
| 1:30 - 2:00 PM | PLENARY SESSION: Antibodies to C1q in SLE |
Betty Diamond, M.D. |
| Session: Complement and Disease - II | ||
| 2:15 PM | C3-dependent microglial priming caused by deletion of the membrane complement regulator Crry Valeria Ramaglia1, Timothy R. Hughes1, Rossen M. Donev1, Marieta M. Ruseva1, Xiaobo Wu3, James W. Neal2, B. Paul Morgan1* |
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| 2:30 PM | Regulation of neuronal gene and miRNA expression by the complement protein C1q associated with neuroprotection Marie Benoit and Andrea J. Tenner |
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| 2:45 PM | Inhibition of the Human Complement Component C4 by Flavivirus Non-structural Protein NS1 Panisadee Avirutnan^1,4, Anja Fuchs^1, Richard E. Hauhart^1, Pawit Somnuke^1,5, Soonjeon Youn^1, Michael S. Diamond^1,2,3, and John P. Atkinson^1,2,3 |
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| 3:00 PM | BREAK | |
| Session: Complement and Disease - III | ||
| 3:15 PM | Functional implications of the recognition of complement factor H-related protein 1 (CFHR1) by anti-factor H autoantibodies in autoimmune haemolytic uraemic syndrome Pilar Sánchez-Corral1, Stefanie Strobel2, Cynthia Abarrategui-Garrido1, Harald Seeberger2, Elena Fariza-Requejo1, Mihály Józsi2 |
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| 3:30 PM | Novel C3 convertase gain of function in atypical haemolytic uraemic syndrome, caused by a frequent mutation in C3 Lubka T. Roumenina1, Marie Frimat2,, Christophe Hue1, Sophie Chauvet1, Sylvain Bigot2, Simon C. Satchell3, Peter W. Mathieson3, Catherine Sautes–Fridman1, John Atkinson 4, Lise Halbwachs-Mecarelli2 , Arnaud Lionet5 and Veronique Fremeaux-Bacchi1,6 |
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| 3:45 PM | A novel hybrid complement gene associated with familial haemolytic uraemic syndrome Nigel J Francis^1, Claire Harris^1, Bairbre McNicholas^2, Atif Awan^3, Donal Reddan^2, Denise Sadlier^4, David Kavanagh^5, Lisa Strain^6, Kevin J. Marchbank^5, Timothy H J Goodship^5 |
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| 4:00 PM | Two N-terminal factor H mutations linked to aHUS cause defects in fluid-phase and cell-surface complement regulatory functions Isabell Pechtl1, David Kavanagh2, Claire Harris3, and Paul N Barlow1 |
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| 4:15 PM | Factor H protects stressed but not quiescent glomerular endothelial cells from complement-mediated damage Lubka T. Roumenina1, Marie Frimat2, Caroline Poitou2, Michal Malina1,3,4, Sylvain Bigot2, Marie-Agnès Dragon-Durey1,5, Simon C. Satchell6, Peter W. Mathieson6, Lise Halbwachs-Mecarelli2 and Veronique Fremeaux-Bacchi1,5 |
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| 7:30 - 11:00 PM | GALA DINNER | |